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Cardizem, a calcium channel blocker, dilates blood vessels and slows the heart to reduce blood pressure and the pain of angina. Since there have been conflicting results regarding the effect of digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing Cardizem therapy to avoid possible over- or under-digitalization. Experience with the use of Cardizem alone or in combination with beta-blockers in patients with impaired ventricular function is very limited. Cardizem has been shown to produce increases in exercise tolerance, probably due to its ability to reduce myocardial oxygen demand. Decreases in blood pressure associated with Cardizem therapy may occasionally result in symptomatic hypotension.
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